A versatile synthetic route to the preparation of ¹⁵ N heterocycles.

ABSTRACT: A robust medium-scale (approximately 3 g) synthetic method for ¹⁵ N labeling of pyridine (¹⁵ N-Py) is reported based on the Zincke reaction. ¹⁵ N enrichment in excess of 81% was achieved with approximately 33% yield. ¹⁵ N-Py serves as a standard substrate in a wide range of studies employing a hyperpolarization technique for efficient polarization transfer from parahydrogen to heteronuclei; this technique, called SABRE (signal amplification by reversible exchange), employs a simultaneous chemical exchange of parahydrogen and a to-be-hyperpolarized substrate (e.g., pyridine) on metal centers. In studies aimed at the development of hyperpolarized contrast agents for in vivo molecular imaging, pyridine is often employed either as a model substrate (

SUBMITTER: Chukanov NV 

PROVIDER: S-EPMC6559877 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature