Soluble receptor for AGE in diabetic nephropathy and its progression in Finnish individuals with type 1 diabetes.

ABSTRACT:

Aims/hypothesis

Activation of the receptor for AGE (RAGE) has been shown to be associated with diabetic nephropathy. The soluble isoform of RAGE (sRAGE) is considered to function as a decoy receptor for RAGE ligands and thereby protects against diabetic complications. A possible association between sRAGE and diabetic nephropathy is still, however, controversial and a more comprehensive analysis of sRAGE with respect to diabetic nephropathy in type 1 diabetes is therefore warranted.

Methods

sRAGE was measured in baseline serum samples from 3647 participants with type 1 diabetes from the nationwide multicentre Finnish Diabetic Nephropathy (FinnDiane) Study. Associations between sRAGE and diabetic nephropathy, as well as sRAGE and diabetic nephropathy progression, were evaluate

SUBMITTER: Waden JM 

PROVIDER: S-EPMC6559996 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature