Genome-wide association study of type 2 diabetes in Africa.

ABSTRACT:

Aims/hypothesis

Genome-wide association studies (GWAS) for type 2 diabetes have uncovered >400 risk loci, primarily in populations of European and Asian ancestry. Here, we aimed to discover additional type 2 diabetes risk loci (including African-specific variants) and fine-map association signals by performing genetic analysis in African populations.

Methods

We conducted two type 2 diabetes genome-wide association studies in 4347 Africans from South Africa, Nigeria, Ghana and Kenya and meta-analysed both studies together. Likely causal variants were identified using fine-mapping approaches.

Results

The most significantly associated variants mapped to the widely replicated type 2 diabetes risk locus near TCF7L2 (p = 5.3 × 10^-13). Fine-mapping of the TCF7L2 l

SUBMITTER: Chen J 

PROVIDER: S-EPMC6560001 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature