Bone marrow pericyte dysfunction in individuals with type 2 diabetes.

ABSTRACT:

Aims/hypothesis

Previous studies have shown that diabetes mellitus destabilises the integrity of the microvasculature in different organs by damaging the interaction between pericytes and endothelial cells. In bone marrow, pericytes exert trophic functions on endothelial cells and haematopoietic cells through paracrine mechanisms. However, whether bone marrow pericytes are a target of diabetes-induced damage remains unknown. Here, we investigated whether type 2 diabetes can affect the abundance and function of bone marrow pericytes.

Methods

We conducted an observational clinical study comparing the abundance and molecular/functional characteristics of CD146⁺ pericytes isolated from the bone marrow of 25 individuals without diabetes and 14 individuals with uncompli

SUBMITTER: Mangialardi G 

PROVIDER: S-EPMC6560025 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature