Arsenic trioxide inhibits liver cancer stem cells and metastasis by targeting SRF/MCM7 complex.

ABSTRACT: Hepatocellular carcinoma (HCC) has a high mortality rate due to the lack of effective treatments and drugs. Arsenic trioxide (ATO), which has been proved to successfully treat acute promyelocytic leukemia (APL), was recently reported to show therapeutic potential in solid tumors including HCC. However, its anticancer mechanisms in HCC still need further investigation. In this study, we demonstrated that ATO inhibits tumorigenesis and distant metastasis in mouse models, corresponding with a prolonged mice survival time. Also, ATO was found to significantly decrease the cancer stem cell (CSC)-associated traits. Minichromosome maintenance protein (MCM) 7 was further identified to be a potential target suppressed dramatically by ATO, of which protein expression is increased in patients and sig

SUBMITTER: Wang HY 

PROVIDER: S-EPMC6560089 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature