Refining the Pneumococcal Competence Regulon by RNA Sequencing.

ABSTRACT: Competence for genetic transformation allows the opportunistic human pathogen Streptococcus pneumoniae to take up exogenous DNA for incorporation into its own genome. This ability may account for the extraordinary genomic plasticity of this bacterium, leading to antigenic variation, vaccine escape, and the spread of antibiotic resistance. The competence system has been thoroughly studied, and its regulation is well understood. Additionally, over the last decade, several stress factors have been shown to trigger the competent state, leading to the activation of several stress response regulons. The arrival of next-generation sequencing techniques allowed us to update the competence regulon, the latest report on which still depended on DNA microarray technology. Enabled by the availab

SUBMITTER: Slager J 

PROVIDER: S-EPMC6560143 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature