Mucosa-Associated Microbiota in Gastric Cancer Tissues Compared With Non-cancer Tissues.

ABSTRACT: The link between microbiota and gastric cancer (GC) has attracted widespread attention. However, the phylogenetic profiles of niche-specific microbiota in the tumor microenvironment is still unclear. Here, mucosa-associated microorganisms from 62 pairs of matched GC tissues and adjacent non-cancerous tissues were characterized by 16S rRNA gene sequencing. Functional profiles of the microbiota were predicted using PICRUSt, and a co-occurrence network was constructed to analyze interactions among gastric microbiota. Results demonstrated that mucosa-associated microbiota from cancerous and non-cancerous tissues established micro-ecological systems that differed in composition, structure, interaction networks, and functions. Microbial richness and diversity were increased in cancerous tissues,

SUBMITTER: Chen XH 

PROVIDER: S-EPMC6560205 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature