ApoAI-derived peptide increases glucose tolerance and prevents formation of atherosclerosis in mice.

ABSTRACT:

Aims/hypothesis

Finding new treatment alternatives for individuals with diabetes with severe insulin resistance is highly desired. To identify novel mechanisms that improve glucose uptake in skeletal muscle, independently from insulin levels and signalling, we have explored the therapeutic potential of a short peptide sequence, RG54, derived from apolipoprotein A-I (ApoA-I).

Methods

INS-1E rat clonal beta cells, C2C12 rat muscle myotubes and J774 mouse macrophages were used to study the impact of RG54 peptide on glucose-stimulated insulin secretion, glucose uptake and cholesterol efflux, respectively. GTTs were carried out on diet-induced insulin-resistant and Lepr^db diabetic mouse models treated with RG54 peptide, and the impact of RG54 peptide on atherosclerosis

SUBMITTER: Edmunds SJ 

PROVIDER: S-EPMC6560211 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature