Comparison of treatment planning approaches for spatially fractionated irradiation of deep tumors.

ABSTRACT:

Purpose

The purpose of this work was to compare the dosimetry and delivery times of 3D-conformal (3DCRT)-, volumetric modulated arc therapy (VMAT)-, and tomotherapy-based approaches for spatially fractionated radiation therapy for deep tumor targets.

Methods

Two virtual GRID phantoms were created consisting of 7 "target" cylinders (1-cm diameter) aligned longitudinally along the tumor in a honey-comb pattern, mimicking a conventional GRID block, with 2-cm center-to-center spacing (GRID_2 cm ) and 3-cm center-to-center spacing (GRID_3 cm ), all contained within a larger cylinder (8 and 10 cm in diameter for the GRID_2 cm and GRID_3 cm , respectively). In a single patient, a GRID_3 cm structure was created within the gross tumo

SUBMITTER: Sheikh K 

PROVIDER: S-EPMC6560243 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature