Predictability in the evolution of Orthopteran cardenolide insensitivity.

ABSTRACT: The repeated evolutionary specialization of distantly related insects to cardenolide-containing host plants provides a stunning example of parallel adaptation. Hundreds of herbivorous insect species have independently evolved insensitivity to cardenolides, which are potent inhibitors of the alpha-subunit of Na⁺,K⁺-ATPase (ATPα). Previous studies investigating ATPα-mediated cardenolide insensitivity in five insect orders have revealed remarkably high levels of parallelism in the evolution of this trait, including the frequent occurrence of parallel amino acid substitutions at two sites and recurrent episodes of duplication followed by neo-functionalization. Here we add data for a sixth insect order, Orthoptera, which includes an ancient group of highly aposematic carde

SUBMITTER: Yang L 

PROVIDER: S-EPMC6560278 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature