Age at Menopause and Risk of Developing Endometrial Cancer: A Meta-Analysis.

ABSTRACT:

Object

The association of age at menopause with endometrial cancer remains controversial. Therefore, we quantitatively summarized the evidence from observational studies with a meta-analysis.

Methods

We searched PubMed, Web of Science, Embase, Medline, Chinese National Knowledge Infrastructure (CNKI), and Wan Fang Med online up to March 2019, and all eligible case-control and cohort studies were included in the study. Pooled relative risks (RRs) with 95% confidence intervals (CIs) were calculated using the random-effects model. The dose-response relationship was assessed by restricted cubic spline model. The heterogeneity among studies was evaluated by I². Metaregression was used to explore the potential sources of between-study heterogeneity. Egger's test was use

SUBMITTER: Wu Y 

PROVIDER: S-EPMC6560333 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature