Neutrophils acquire antigen-presenting cell features after phagocytosis of IgG-opsonized erythrocytes.

ABSTRACT: Neutrophils are particularly well known for their antimicrobial function. Although historically they are regarded as strictly a phagocyte of the innate immune system, over time it has become clear that neutrophils are versatile cells with numerous functions including innate and adaptive immune regulation. We have previously described a role for human neutrophils in antibody-mediated red blood cell (RBC) clearance. Under homeostatic conditions, neutrophils do not take up RBCs. Yet, when RBCs are immunoglobulin G (IgG) opsonized, which can occur in alloimmunization or autoimmunization reactions, neutrophils can effectively phagocytose RBCs. In the present study, we show that human neutrophils acquire an antigen-presenting cell (APC) phenotype following RBC phagocytosis. Subsequent to RBC pha

SUBMITTER: Meinderts SM 

PROVIDER: S-EPMC6560339 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature