Human peripheral blood DNAM-1^neg NK cells are a terminally differentiated subset with limited effector functions.

ABSTRACT: Natural killer (NK) cells are a heterogeneous population of innate lymphocytes whose potent anticancer properties make them ideal candidates for cellular therapeutic application. However, our lack of understanding of the role of NK cell diversity in antitumor responses has hindered advances in this area. In this study, we describe a new CD56^dim NK cell subset characterized by the lack of expression of DNAX accessory molecule-1 (DNAM-1). Compared with CD56^bright and CD56^dimDNAM-1^pos NK cell subsets, CD56^dimDNAM-1^neg NK cells displayed reduced motility, poor proliferation, lower production of interferon-γ, and limited killing capacities. Soluble factors secreted by CD56^dimDNAM-1^neg NK cells impaired CD56<

SUBMITTER: Stannard KA 

PROVIDER: S-EPMC6560343 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature