The Transcription Factor Sfp1 Regulates the Oxidative Stress Response in Candida albicans.

ABSTRACT: Candida albicans is a commensal that inhabits the skin and mucous membranes of humans. Because of the increasing immunocompromised population and the limited classes of antifungal drugs available, C. albicans has emerged as an important opportunistic pathogen with high mortality rates. During infection and therapy, C. albicans frequently encounters immune cells and antifungal drugs, many of which exert their antimicrobial activity by inducing the production of reactive oxygen species (ROS). Therefore, antioxidative capacity is important for the survival and pathogenesis of C. albicans. In this study, we characterized the roles of the zinc finger transcription factor Sfp1 in the oxidative stress response against C. albicans. A sfp1-del

SUBMITTER: Lee SY 

PROVIDER: S-EPMC6560436 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature