Molecular Origins of Complex Heritability in Natural Genotype-to-Phenotype Relationships.

ABSTRACT: The statistical complexity of heredity has long been evident, but its molecular origins remain elusive. To investigate, we charted 90 comprehensive genotype-to-phenotype maps in a large population of wild diploid yeast. In contrast to long-standing assumptions, all types of genetic variation contributed similarly to phenotype. Causal synonymous and regulatory variants exhibited distinct molecular signatures, as did nonlinearities in heterozygote fitness that likely contribute to hybrid vigor. Highly pleiotropic variants altered disordered sequences within signaling hubs, and their effects correlated across environments-even when antagonistic-suggesting that large fitness gains bring concomitant costs. Natural genetic networks defined by the causal loci differed from those determined by pre

SUBMITTER: Jakobson CM 

PROVIDER: S-EPMC6560647 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature