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Diverse regulatory manners of human telomerase reverse transcriptase.


ABSTRACT: Human telomerase reverse transcriptase (hTERT) is the core subunit of human telomerase and plays important roles in human cancers. Aberrant expression of hTERT is closely associated with tumorigenesis, cancer cell stemness maintaining, cell proliferation, apoptosis inhibition, senescence evasion and metastasis. The molecular basis of hTERT regulation is highly complicated and consists of various layers. A deep and full-scale comprehension of the regulatory mechanisms of hTERT is pivotal in understanding the pathogenesis and searching for therapeutic approaches. In this review, we summarize the recent advances regarding the diverse regulatory mechanisms of hTERT, including the transcriptional (promoter mutation, promoter region methylation and histone acetylation), post-transcriptional (mRNA alternative splicing and non-coding RNAs) and post-translational levels (phosphorylation and ubiquitination), which may provide novel perspectives for further translational diagnosis or therapeutic strategies targeting hTERT.

SUBMITTER: Jie MM 

PROVIDER: S-EPMC6560729 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature

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Diverse regulatory manners of human telomerase reverse transcriptase.

Jie Meng-Meng MM   Chang Xing X   Zeng Shuo S   Liu Cheng C   Liao Guo-Bin GB   Wu Ya-Ran YR   Liu Chun-Hua CH   Hu Chang-Jiang CJ   Yang Shi-Ming SM   Li Xin-Zhe XZ  

Cell communication and signaling : CCS 20190611 1


Human telomerase reverse transcriptase (hTERT) is the core subunit of human telomerase and plays important roles in human cancers. Aberrant expression of hTERT is closely associated with tumorigenesis, cancer cell stemness maintaining, cell proliferation, apoptosis inhibition, senescence evasion and metastasis. The molecular basis of hTERT regulation is highly complicated and consists of various layers. A deep and full-scale comprehension of the regulatory mechanisms of hTERT is pivotal in under  ...[more]

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2024-07-11 | GSE145659 | GEO