BET protein inhibition regulates cytokine production and promotes neuroprotection after spinal cord injury.

ABSTRACT:

Background

Spinal cord injury (SCI) usually causes a devastating lifelong disability for patients. After a traumatic lesion, disruption of the blood-spinal cord barrier induces the infiltration of macrophages into the lesion site and the activation of resident glial cells, which release cytokines and chemokines. These events result in a persistent inflammation, which has both detrimental and beneficial effects, but eventually limits functional recovery and contributes to the appearance of neuropathic pain. Bromodomain and extra-terminal domain (BET) proteins are epigenetic readers that regulate the expression of inflammatory genes by interacting with acetylated lysine residues. While BET inhibitors are a promising therapeutic strategy for cancer, little is known about their implica

SUBMITTER: Sanchez-Ventura J 

PROVIDER: S-EPMC6560758 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature