Clinical relevance of alerts from a decision support system, PHARAO, for drug safety assessment in the older adults.

ABSTRACT:

Background

PHARAO is a decision support system developed to evaluate the risk for a set of either common or serious side-effects resulting from a combination of pharmacodynamic effects from a patient's medications. The objective of this study was to investigate the validity of the risk scores for the common side-effects generated by PHARAO in older patients.

Methods

Side-effects included were sedation, constipation, orthostatic symptoms, anticholinergic and serotonergic effects. The alerts generated by PHARAO were tested in 745 persons ≥65 years old. Dispensed prescriptions retrieved from the Swedish prescribed drug register were used to generate the pharmacological risk scores of patients' medications. Symptoms possibly related to side-effects were extracted from medical re

SUBMITTER: Hedna K 

PROVIDER: S-EPMC6560851 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature