The FTO Gene and Measured Food Intake in 5- to 10-Year-Old Children Without Obesity.

ABSTRACT:

Objective

Genetic variation in the first intron of FTO (e.g., single-nucleotide polymorphism [SNP] rs9939609) is strongly associated with adiposity. This effect is thought to be mediated (at least in part) via increasing caloric intake, although the precise molecular genetic mechanisms are not fully understood. Prior pediatric studies of FTO have included youth with overweight and obesity; however, they have not informed whether a genotypic effect on ingestive behavior is present prior to obesity onset. Therefore, this study investigated the association between FTO and caloric intake in children aged 5 to 10 years without obesity (adiposity ≤ 95th percentile).

Methods

A total of 122 children were genotyped for rs9939609 and ate ad libitum from a laboratory lunch buffet follo

SUBMITTER: Ranzenhofer LM 

PROVIDER: S-EPMC6561098 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature