Estrogen receptor signaling is reprogrammed during breast tumorigenesis.

ABSTRACT: Limited knowledge of the changes in estrogen receptor (ER) signaling during the transformation of the normal mammary gland to breast cancer hinders the development of effective prevention and treatment strategies. Differences in estrogen signaling between normal human primary breast epithelial cells and primary breast tumors obtained immediately following surgical excision were explored. Transcriptional profiling of normal ER⁺ mature luminal mammary epithelial cells and ER⁺ breast tumors revealed significant difference in the response to estrogen stimulation. Consistent with these differences in gene expression, the normal and tumor ER cistromes were distinct and sufficient to segregate normal breast tissues from breast tumors. The selective enrichment of the DNA bind

SUBMITTER: Chi D 

PROVIDER: S-EPMC6561257 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature