Diagnosis of obstructive coronary artery disease using computed tomography angiography in patients with stable chest pain depending on clinical probability and in clinically important subgroups: meta-analysis of individual patient data.

ABSTRACT:

Objective

To determine whether coronary computed tomography angiography (CTA) should be performed in patients with any clinical probability of coronary artery disease (CAD), and whether the diagnostic performance differs between subgroups of patients.

Design

Prospectively designed meta-analysis of individual patient data from prospective diagnostic accuracy studies.

Data sources

Medline, Embase, and Web of Science for published studies. Unpublished studies were identified via direct contact with participating investigators.

Eligibility criteria for selecting studies

Prospective diagnostic accuracy studies that compared coronary CTA with coronary angiography as the reference standard, using at least a 50% diameter reduction as a cutoff value for obstructive CAD.

SUBMITTER: Haase R 

PROVIDER: S-EPMC6561308 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature