Sirtuin/uncoupling protein gene variants and carotid plaque area and morphology.

ABSTRACT:

Background

Sirtuins and uncoupling proteins have been implicated in cardiovascular diseases by controlling oxidative stress.

Aims

We sought to investigate the association of sirtuins and uncoupling proteins single nucleotide polymorphisms with total carotid plaque area and morphology measured by ultrasonographic gray scale median.

Methods

We analyzed 1356 stroke-free subjects (60% women, mean age = 68 ± 9 years) from the Northern Manhattan Study. Multiple linear regression models were used to evaluate the association of 85 single nucleotide polymorphisms in 11 sirtuins/uncoupling protein genes with total plaque area and gray scale median after controlling for demographics, vascular risk factors (RFs), and population stratification. We investigated effect modifications

SUBMITTER: Dong C 

PROVIDER: S-EPMC6561468 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature