A multiscale hybrid mathematical model of epidermal-dermal interactions during skin wound healing.

ABSTRACT: Following injury, skin activates a complex wound healing programme. While cellular and signalling mechanisms of wound repair have been extensively studied, the principles of epidermal-dermal interactions and their effects on wound healing outcomes are only partially understood. To gain new insight into the effects of epidermal-dermal interactions, we developed a multiscale, hybrid mathematical model of skin wound healing. The model takes into consideration interactions between epidermis and dermis across the basement membrane via diffusible signals, defined as activator and inhibitor. Simulations revealed that epidermal-dermal interactions are critical for proper extracellular matrix deposition in the dermis, suggesting these signals may influence how wound scars form. Our model makes seve

SUBMITTER: Wang Y 

PROVIDER: S-EPMC6561509 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature