MicroRNA expression profile in retina and choroid in oxygen-induced retinopathy model.

ABSTRACT:

Background

Ischemic retinopathies (IRs) are leading causes of visual impairment. They are characterized by an initial phase of microvascular degeneration and a second phase of aberrant pre-retinal neovascularization (NV). microRNAs (miRNAs) regulate gene expression, and a number play a role in normal and pathological NV. But, post-transcriptional modulation of miRNAs in the eye during the development of IRs has not been systematically evaluated.

Aims & methods

Using Next Generation Sequencing (NGS) we profiled miRNA expression in the retina and choroid during vasodegenerative and NV phases of oxygen-induced retinopathy (OIR).

Results

Approximately 20% of total miRNAs exhibited altered expression (up- or down-regulation); 6% of miRNA were found highly expressed in reti

SUBMITTER: Desjarlais M 

PROVIDER: S-EPMC6561584 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature