Exploring non-retention in clinical trials: a meta-ethnographic synthesis of studies reporting participant reasons for drop out.

ABSTRACT:

Objectives

To undertake a meta-ethnographic synthesis of findings from primary studies reporting qualitative data that have explored participant-reported factors influencing non-retention within a clinical trial context.

Design

A systematic search and meta-ethnography was conducted for published papers (from 1946 to July 2018) that contained qualitative data from trial non-retainers.

Participants

We identified 11 studies reporting qualitative data from 13 trials. The studies were undertaken between 2008 and 2018. Each study included between 3 and 40 people who had dropped out from a trial, with findings from 168 people in total reported across the papers.

Results

Emergent from our synthesis was the significance of trial non-retainers' perceptions around the per

SUBMITTER: Skea ZC 

PROVIDER: S-EPMC6561611 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature