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Stabilizing spin systems via symmetrically tailored RKKY interactions.

ABSTRACT: Spins of single atoms adsorbed on substrates are promising building blocks for spintronics and quantum computation schemes. To process spin information and for increased magnetic stability, these spins have to be coupled to arrays. For a single atom, a high symmetry of the environment increases its spin stability. However, little is known about the role of the symmetry of the magnetic couplings in the arrays. Here, we study arrays of atomic spins coupled via Ruderman-Kittel-Kasuya-Yosida interaction, focusing on Dzyaloshinskii-Moriya and symmetric anisotropic exchange. We show that the high spin stability of a trimer can be remotely detected by a nearby atom, and how the Dzyaloshinskii-Moriya interaction leads to its destabilization. Adding more nearby atoms further destabilizes the trimer, due to a non-local effective transverse anisotropy originating in the symmetric anisotropic exchange. This transverse anisotropy can be quenched for highly symmetric structures, where the spin lifetime of the array increases drastically.

SUBMITTER: Hermenau J

PROVIDER: S-EPMC6561942 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature

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Stabilizing spin systems via symmetrically tailored RKKY interactions.

Hermenau Jan J Brinker Sascha S Marciani Marco M Steinbrecher Manuel M Dos Santos Dias Manuel M Wiesendanger Roland R Lounis Samir S Wiebe Jens J

Nature communications 20190612 1

Spins of single atoms adsorbed on substrates are promising building blocks for spintronics and quantum computation schemes. To process spin information and for increased magnetic stability, these spins have to be coupled to arrays. For a single atom, a high symmetry of the environment increases its spin stability. However, little is known about the role of the symmetry of the magnetic couplings in the arrays. Here, we study arrays of atomic spins coupled via Ruderman-Kittel-Kasuya-Yosida interac ...[more]

PMID: 31189872

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Project description:Glomerular podocytes are highly differentiated cells that are key components of the kidney filtration units. The podocyte cytoskeleton builds the basis for the dynamic podocyte cytoarchitecture and plays a central role for proper podocyte function. Recent studies implicate that immunosuppressive agents including the mTOR-inhibitor everolimus have a protective role directly on the stability of the podocyte cytoskeleton. To elucidate mechanisms underlying mTOR-inhibitor mediated cytoskeletal rearrangements, we carried out microarray gene expression studies to identify target genes and corresponding pathways in response to everolimus. We analyzed the effect of everolimus in a puromycin aminonucleoside experimental in vitro model of podocyte injury. Upon treatment with puromycin aminonucleoside, microarray analysis revealed gene clusters involving cytoskeletal-associated pathways, adhesion, migration and extracellular matrix composition to be affected. Everolimus is capable of protecting podocytes from injury, both on the transcriptome and protein level. Rescued genes included TUBB2B and DCDC2, both involved in microtubule structure formation in neuronal cells but not identified in podocytes so far. Confirming gene expression data, Western-blot analysis in cultured podocytes showed an increase of TUBB2B and DCDC2 protein after everolimus treatment, and immunohistochemistry in healthy control kidneys confirmed a podocyte-specific expression. Microtubule-inhibitor experiments led to a maldistribution of TUBB2B and DCDC2 as well as an aberrant reorganization of the actin cytoskeleton. Tubb2bbrdp/brdp mice showed a delay in glomerular podocyte and capillary development. Taken together, our study suggests that off-target, non-immune mediated effects of the mTOR-inhibitor everolimus on the podocyte cytoskeleton might involve regulation of microtubules, revealing a potential novel role of TUBB2B and DCDC2 in glomerular podocyte development We analyzed the effect of everolimus on gene expression in a puromycin aminonucleoside experimental in vitro model of podocyte injury using microarrays

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Stabilizing spin systems via symmetrically tailored RKKY interactions.

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Stabilizing spin systems via symmetrically tailored RKKY interactions.

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