Signaling pathway network alterations in human ovarian cancers identified with quantitative mitochondrial proteomics.

ABSTRACT:

Relevance

Molecular network changes are the hallmark of the pathogenesis of ovarian cancers (OCs). Network-based biomarkers benefit for the effective treatment of OC.

Purpose

This study sought to identify key pathway-network alterations and network-based biomarkers for clarification of molecular mechanisms and treatment of OCs.

Methods

Ingenuity Pathway Analysis (IPA) platform was used to mine signaling pathway networks with 1198 human tissue mitochondrial differentially expressed proteins (mtDEPs) and compared those pathway network changes between OCs and controls. The mtDEPs in important cancer-related pathway systems were further validated with qRT-PCR and Western blot in OC cell models. Moreover, integrative analysis of mtDEPs and Cancer Genome Atlas (TCGA) data f

SUBMITTER: Li N 

PROVIDER: S-EPMC6562010 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature