Geographic Variation and Bias in the Polygenic Scores of Complex Diseases and Traits in Finland.

ABSTRACT: Polygenic scores (PSs) are becoming a useful tool to identify individuals with high genetic risk for complex diseases, and several projects are currently testing their utility for translational applications. It is also tempting to use PSs to assess whether genetic variation can explain a part of the geographic distribution of a phenotype. However, it is not well known how the population genetic properties of the training and target samples affect the geographic distribution of PSs. Here, we evaluate geographic differences, and related biases, of PSs in Finland in a geographically well-defined sample of 2,376 individuals from the National FINRISK study. First, we detect geographic differences in PSs for coronary artery disease (CAD), rheumatoid arthritis, schizophrenia, waist-hip ratio (WHR

SUBMITTER: Kerminen S 

PROVIDER: S-EPMC6562021 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature