Internodular functional connectivity in heterotopia-related epilepsy.

ABSTRACT:

Objective

A vast network involving the nodules and overlying cortices is believed to be responsible for the epileptogenicity in gray matter heterotopia with multiple nodules, which often associated with difficult-to-treat epilepsy. We sought to determine if functional magnetic resonance imaging (fMRI) could detect internodular functional connectivity (FC), and if this connectivity reflects an actual synchronized neuronal activity and partakes in epileptogenicity.

Methods

We studied 16 epilepsy patients with multiple heterotopic nodules; eight underwent subsequent intracerebral EEG. We examined the internodular FC using fMRI and its correspondence with internodular synchrony of intracerebral interictal activity. We then compared the spreading speed of ictal activity between c

SUBMITTER: Khoo HM 

PROVIDER: S-EPMC6562032 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature