CSF Neurofilament light chain level predicts axonal damage in cerebral vasculitis.

ABSTRACT: The rarity of primary angiitis of the central nervous system (PACNS) demands diagnostic and prognostic biomarkers. We retrospectively measured Neurofilament light chain (NFL) concentrations in cerebrospinal fluid in a severely relapsing PACNS patient at multiple time points during the course of the disease. A marked increase in NFL levels preceding the onset of neuro-axonal damage and arterial-vessel abnormalities was observed with magnetic resonance imaging as well as with MR- and conventional angiography. Thus, marked elevation of NFL in PACNS seems to occur ahead of definitive radiological abnormalities and might serve as a diagnostic biomarker.

SUBMITTER: Pawlitzki M 

PROVIDER: S-EPMC6562033 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature