MiRNA contributions to pediatric-onset multiple sclerosis inferred from GWAS.

ABSTRACT:

Objective

Onset of multiple sclerosis (MS) occurs in childhood for approximately 5% of cases (pediatric MS, or ped-MS). Epigenetic influences are strongly implicated in MS pathogenesis in adults, including the contribution from microRNAs (miRNAs), small noncoding RNAs that affect gene expression by binding target gene mRNAs. Few studies have specifically examined miRNAs in ped-MS, but individuals developing MS at an early age may carry a relatively high burden of genetic risk factors, and miRNA dysregulation may therefore play a larger role in the development of ped-MS than in adult-onset MS. This study aimed to look for evidence of miRNA involvement in ped-MS pathogenesis.

Methods

GWAS results from 486 ped-MS cases and 1362 controls from the U.S. Pediatric MS Network and Ka

SUBMITTER: Rhead B 

PROVIDER: S-EPMC6562070 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature