Virulence behavior of uropathogenic Escherichia coli strains in the host model Caenorhabditis elegans.

ABSTRACT: Urinary tract infections (UTIs) are among the most common bacterial infections in humans. Although a number of bacteria can cause UTIs, most cases are due to infection by uropathogenic Escherichia coli (UPEC). UPEC are a genetically heterogeneous group that exhibit several virulence factors associated with colonization and persistence of bacteria in the urinary tract. Caenorhabditis elegans is a tiny, free-living nematode found worldwide. Because many biological pathways are conserved in C. elegans and humans, the nematode has been increasingly used as a model organism to study virulence mechanisms of microbial infections and innate immunity. The virulence of UPEC strains, characterized for antimicrobial resistance, pathogenicity-related genes associated with virulence and phylogenetic gro

SUBMITTER: Schifano E 

PROVIDER: S-EPMC6562141 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature