In vitro sensitivity of malignant melanoma cells lines to photon and heavy ion radiation.

ABSTRACT:

Background

The role of radiotherapy in malignant melanoma is still in discussion due to its relative resistance to radiation. In various literature, heavy ions show a higher relative biological effectiveness than photons. The aim of this work is to evaluate the radiotherapeutical effect from photons as well as heavy ions on malignant melanoma cells and to indicate the possible radiosensitivity based on its proliferation-inhibitory effect.

Methods

Two different cell lines of malignant melanoma, WM115 (primary tumor) and WM266-4 (metastatic site, skin) were used in this in vitro study. The cells were treated with photons or heavy ions (C₁₂ and O₁₆ ions). Cell-proliferation assay using hemocytometer was used for the quantitative and qualitative evaluation

SUBMITTER: Aninditha KP 

PROVIDER: S-EPMC6562297 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature