New Insights into Molecular Oncogenesis and Therapy of Uveal Melanoma.

ABSTRACT: Uveal melanoma (UM), which is the most common cancer of the eye, was investigated in recent years by many teams in the field of biomedical sciences and eye clinicians. New knowledge was acquired on molecular pathways found to be dysregulated during the multistep process of oncogenesis, whereas novel therapeutic approaches gave significant results in the clinical applications. Uveal melanoma-affected patients greatly benefited from recent advances of the research in this eye cancer. Tumour biology, genetics, epigenetics and immunology contributed significantly in elucidating the role of different genes and related pathways during uveal melanoma onset/progression and UM treatments. Indeed, these investigations allowed identification of new target genes and to develop new therapeutic strategi

SUBMITTER: Violanti SS 

PROVIDER: S-EPMC6562554 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature