Altered Gene Response to Aflatoxin B₁ in the Spleens of Susceptible and Resistant Turkeys.

ABSTRACT: Susceptibility and/or resistance to aflatoxin B₁ (AFB₁) is a threshold trait governed principally by glutathione S transferase (GST)-mediated detoxification. In poultry, domesticated turkeys are highly sensitive to AFB₁, most likely due to dysfunction in hepatic GSTs. In contrast, wild turkeys are comparatively resistant to aflatoxicosis due to the presence of functional hepatic GSTAs and other possible physiological and immunological interactions. The underlying genetic basis for the disparate GST function in turkeys is unknown as are the broader molecular interactions that control the systemic response. This study quantifies the effects of dietary AFB₁ on gene expression in the turkey spleen, specifically contrasting genetically distinct domest

SUBMITTER: Reed KM 

PROVIDER: S-EPMC6562755 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature