Prognostic Significance of Serum Free Amino Acids in Head and Neck Cancers.

ABSTRACT: Despite distinctive advances in the field of head and neck squamous cell cancer (HNSCC) biomarker discovery, the spectrum of clinically useful prognostic serum biomarkers is limited. As metabolic activities in highly proliferative transformed cells are fundamentally different from those in non-transformed cells, specific shifts in concentration of different metabolites may serve as diagnostic or prognostic markers. Blood amino acids have been identified as promising biomarkers in different cancers before, but little is known about this field in HNSCC. Blood amino acid profiles of 140 HNSCC patients were examined using high-performance liquid chromatography. Cox proportional hazards regression model was used to assess the prognostic value of amino acid concentrations in serum. Colony formin

SUBMITTER: Vsiansky V 

PROVIDER: S-EPMC6562773 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature