Hair of the Dog: Identification of a Cis-Regulatory Module Predicted to Influence Canine Coat Composition.

ABSTRACT: Each domestic dog breed is characterized by a strict set of physical and behavioral characteristics by which breed members are judged and rewarded in conformation shows. One defining feature of particular interest is the coat, which is comprised of either a double- or single-layer of hair. The top coat contains coarse guard hairs and a softer undercoat, similar to that observed in wolves and assumed to be the ancestral state. The undercoat is absent in single-coated breeds which is assumed to be the derived state. We leveraged single nucleotide polymorphism (SNP) array and whole genome sequence (WGS) data to perform genome-wide association studies (GWAS), identifying a locus on chromosome (CFA) 28 which is strongly associated with coat number. Using WGS data, we identified a locus of 18.4

SUBMITTER: Whitaker DT 

PROVIDER: S-EPMC6562840 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature