The Prognostic and Therapeutic Potential of LRIG3 and Soluble LRIG3 in Glioblastoma.

ABSTRACT: Glioblastoma is a highly lethal type of primary brain tumor that exhibits unrestricted growth and aggressive invasion capabilities, leading to a dismal prognosis despite a multitude of therapies. Multiple alterations in the expression level of genes and/or proteins have been identified in glioblastomas, including the activation of oncogenes and/or silencing of tumor-suppressor genes. Nevertheless, there are still no effective targeted therapies associated with these changes. In this study, we investigated the expression of human leucine-rich repeats and immunoglobulin-like domains protein 3 (LRIG3) in human glioma specimens through immunohistochemical analysis. The results showed that LRIG3 was weakly expressed in high-grade gliomas (WHO [World Health Organization] grades III and IV) compa

SUBMITTER: Cheng F 

PROVIDER: S-EPMC6563081 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature