Distribution and Evolution of Nonribosomal Peptide Synthetase Gene Clusters in the Ceratocystidaceae.

ABSTRACT: In filamentous fungi, genes in secondary metabolite biosynthetic pathways are generally clustered. In the case of those pathways involved in nonribosomal peptide production, a nonribosomal peptide synthetase (NRPS) gene is commonly found as a main element of the cluster. Large multifunctional enzymes are encoded by members of this gene family that produce a broad spectrum of bioactive compounds. In this research, we applied genome-based identification of nonribosomal peptide biosynthetic gene clusters in the family Ceratocystidaceae. For this purpose, we used the whole genome sequences of species from the genera Ceratocystis,Davidsoniella,Thielaviopsis, Endoconidiophora,Bretziella, Huntiella, and Ambrosiella. To identify and character

SUBMITTER: Sayari M 

PROVIDER: S-EPMC6563098 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature