Tripping the light fantastic in membrane redox biology: linking dynamic structures to function in ER electron transfer chains.

ABSTRACT: How the dynamics of proteins assist catalysis is a contemporary issue in enzymology. In particular, this holds true for membrane-bound enzymes, where multiple structural, spectroscopic and biochemical approaches are needed to build up a comprehensive picture of how dynamics influence enzyme reaction cycles. Of note are the recent studies of cytochrome P450 reductases (CPR)-P450 (CYP) endoplasmic reticulum redox chains, showing the relationship between dynamics and electron flow through flavin and haem redox centres and the impact this has on monooxygenation chemistry. These studies have led to deeper understanding of mechanisms of electron flow, including the timing and control of electron delivery to protein-bound cofactors needed to facilitate CYP-catalysed reactions. Individual and mult

SUBMITTER: Hedison TM 

PROVIDER: S-EPMC6563164 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature