Still Something to Discover: Novel Insights into<i>Escherichia coli</i> Phage Diversity and Taxonomy.

ABSTRACT: The aim of this study was to gain further insight into the diversity of Escherichia coli phagesfollowed by enhanced work on taxonomic issues in that field. Therefore, we present the genomiccharacterization and taxonomic classification of 50 bacteriophages against E. coli isolated fromvarious sources, such as manure or sewage. All phages were examined for their host range on a setof different E. coli strains, originating, e.g., from human diagnostic laboratories or poultry farms.Transmission electron microscopy revealed a diversity of morphotypes (70% Myo-, 22% Sipho-, and8% Podoviruses), and genome sequencing resulted in genomes sizes from ~44 to ~370 kb.Annotation and comparison with databases showed similarities in particular to T4- and T5-likephages, but also to less-known

SUBMITTER: Korf IHE 

PROVIDER: S-EPMC6563267 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature