Epidemiological, Molecular, and Clinical Features of Norovirus Infections among Pediatric Patients in Qatar.

ABSTRACT:

Background

Norovirus (NoV) is recognized as the second most important etiological agent leading to acute gastroenteritis globally. In order to determine the burden and characteristics of NoV infections in children in Qatar, profiling of circulating genotypes and their correlation with demographics and clinical manifestations were evaluated.

Methods

A total of 177 NoV-positive fecal samples were collected from children suffering from acute gastroenteritis (AGE) during two-year period between June 2016 and June 2018. The age of the subjects ranged between 3 months and 12 years (median of 15 months). Genotyping was performed by amplifying and sequencing parts of viral VP1 and RNA-dependent RNA polymerase (RdRp) regions. Phylogenetic analysis and evolutionary relationships were

SUBMITTER: Mathew S 

PROVIDER: S-EPMC6563317 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature