Ontology highlight
ABSTRACT:
SUBMITTER: Korpershoek E
PROVIDER: S-EPMC6563419 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Korpershoek Esther E Dieduksman Daphne A E R DAER Grinwis Guy C M GCM Day Michael J MJ Reusch Claudia E CE Hilbe Monika M Fracassi Federico F Krol Niels M G NMG Uitterlinden André G AG de Klein Annelies A Eussen Bert B Stoop Hans H de Krijger Ronald R RR Galac Sara S Dinjens Winand N M WNM
Cancers 20190430 5
8658860258318000Recently, genetic alterations in the genes encoding succinate dehydrogenase subunit B and D (<i>SDHB</i> and <i>SDHD</i>) were identified in pet dogs that presented with spontaneously arising pheochromocytomas (PCC) and paragangliomas (PGL; together PPGL), suggesting dogs might be an interesting comparative model for the study of human PPGL. To study whether canine PPGL resembled human PPGL, we investigated a series of 50 canine PPGLs by immunohistochemistry to determine the expr ...[more]