Analyzing the effects of instillation volume on intravesical delivery using biphasic solute transport in a deformable geometry.

ABSTRACT: Ailments of the bladder are often treated via intravesical delivery-direct application of therapeutic into the bladder through a catheter. This technique is employed hundreds of thousands of times every year, but protocol development has largely been limited to empirical determination. Furthermore, the numerical analyses of intravesical delivery performed to date have been restricted to static geometries and have not accounted for bladder deformation. This study uses a finite element analysis approach with biphasic solute transport to investigate several parameters pertinent to intravesical delivery including solute concentration, solute transport properties and instillation volume. The volume of instillation was found to have a substantial impact on the exposure of solute to the deeper mu

SUBMITTER: Smith SG 

PROVIDER: S-EPMC6563523 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature