Association between VDR gene FokI polymorphism and renal function in patients with IgA nephropathy.

ABSTRACT:

Background

Studies have shown that the occurrence and development of IgA nephropathy (IgAN) are genetically susceptible, but the relationship between vitamin D receptor (VDR) gene polymorphisms and renal function in IgAN patients is unclear.

Methods

We investigated the relationship between VDR FokI (rs2228570) single nucleotide polymorphism (SNP) and renal function and related clinicopathologic parameters in IgAN patients. Clinical and pathological data of 282 IgAN patients treated at the First Affiliated Hospital of Guangxi Medical University were collected, and FokI genotypes were determined by PCR and direct sequencing. Patients were divided into the renal dysfunction group and normal renal function (control) group by estimated glomerular filtration r

SUBMITTER: Mo MQ 

PROVIDER: S-EPMC6563792 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature