Impact of non-brain anatomy and coil orientation on inter- and intra-subject variability in TMS at midline.

ABSTRACT:

Objective

To investigate inter-subject variability with respect to cerebrospinal fluid thickness and brain-scalp distance, and to investigate intra-subject variability with different coil orientations.

Methods

Simulations of the induced electric field (E-Field) using a figure-8 coil over the vertex were conducted on 50 unique head models and varying orientations on 25 models. Metrics exploring stimulation intensity, spread, and localization were used to describe inter-subject variability and effects of non-brain anatomy.

Results

Both brain-scalp distance and CSF thickness were correlated with weaker stimulation intensity and greater spread. Coil rotations show that for the dorsal portion of the stimulated brain, E-Field intensities are highest when the anterior-poster

SUBMITTER: Lee EG 

PROVIDER: S-EPMC6563831 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature