Chronic cocaine administration upregulates FKBP5 in the extended amygdala of male and female rats.

ABSTRACT:

Background

Dysregulation of glucocorticoid receptors has been implicated in addiction and stress-related disorders. FKBP5 is a co-chaperone of the glucocorticoid receptor and regulates receptor sensitivity. While FKBP5 is known to be involved in mood- and stress-related disorders, less is known regarding FKBP5 and cocaine abuse. This study investigated the regulation of FKBP5 expression in the extended amygdala and paraventricular nucleus of the hypothalamus, regions important in the control of stress-responses and HPA axis function, following chronic and acute cocaine administration.

Methods

Adult male and female rats received saline or cocaine three times per day for 1 or 14 days. Brain tissue was collected 30 min, 24 h, 48 h, 7 days or 14 days following the final injectio

SUBMITTER: Connelly KL 

PROVIDER: S-EPMC6563832 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature