Monitoring early response to chemoradiotherapy with ¹⁸F-FMISO dynamic PET in head and neck cancer.

ABSTRACT:

Purpose

There is growing recognition that biologic features of the tumor microenvironment affect the response to cancer therapies and the outcome of cancer patients. In head and neck cancer (HNC) one such feature is hypoxia. We investigated the utility of ¹⁸F-fluoromisonidazole (FMISO) dynamic positron emission tomography (dPET) for monitoring the early microenvironmental response to chemoradiotherapy in HNC.

Experimental design

Seventy-two HNC patients underwent FMISO dPET scans in a customized immobilization mask (0-30 min dynamic acquisition, followed by 10 min static acquisitions starting at ∼95 min and ∼160 min post-injection) at baseline and early into treatment where patients have already received one cycle of chemotherapy and anywhere from five to ten frac

SUBMITTER: Grkovski M 

PROVIDER: S-EPMC6563902 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature