Essential long-range action of Wingless/Wnt in adult intestinal compartmentalization.

ABSTRACT: Signal transduction activated by Wingless/Wnt ligands directs cell proliferation and fate specification in metazoans, and its overactivation underlies the development of the vast majority of colorectal cancers. In the conventional model, the secretion and movement of Wingless to cells distant from its source of synthesis are essential for long-range signaling in tissue patterning. However, this model was upended recently by an unanticipated finding: replacement of wild-type Drosophila Wingless with a membrane-tethered form produced viable adults with largely normal external morphology, which suggested that Wingless secretion and movement are dispensable for tissue patterning. Herein, we tested this foundational principle in the adult intestine, where Wingless signaling gradients coincide w

SUBMITTER: Tian A 

PROVIDER: S-EPMC6563961 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature