Sex differences in sympathetic gene expression and cardiac neurochemistry in Wistar Kyoto rats.

ABSTRACT: The stellate ganglia are the predominant source of sympathetic innervation to the heart. Remodeling of sympathetic nerves projecting to the heart has been observed in several cardiovascular diseases, and sympathetic dysfunction contributes to cardiac pathology. Wistar Kyoto rats are a common model for the study of cardiovascular diseases, but we lack a profile of the baseline transcriptomic and neurochemical characteristics of their cardiac sympathetic neurons. Most studies of cardiovascular disease have used male animals only, but in the future both male and female animals will be used for these types of studies; therefore, we sought to characterize the transcriptome of male and female stellate ganglia and to correlate that with catecholamine and acetylcholine content in the heart. We hav

SUBMITTER: Bayles RG 

PROVIDER: S-EPMC6564003 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature